Spontaneous Remission And Regression In Cancer Patients
Essay by 24 • March 10, 2011 • 2,344 Words (10 Pages) • 1,858 Views
Spontaneous Remission and Regression in Cancer Patients:
What a Mystery!
I. What is Cancer?
Cancer is a disease produced by the invasion or implantation of uncontrolled cell
division in almost any organ or part of the body. As cancerous cells divide and multiply,
they invade the host cells transforming them in abnormal cells due to the damage
produced to their DNA. This process of cell mutation may be slow or fast and, once
mutated, such malignant cells may implant themselves in other parts of the body as they
easily travel in the blood stream and the lymphatic system. Metastasis tends to follow
particular trends depending on the origin of the carcinogenesis.
Diagnosing cancer requires a histological examination of tissue obtained by a biopsy or
surgery and is analyzed by a pathologist. Although there is no cure for cancers, some
treatments are currently used including radiotherapy, chemotherapy and surgery. As
more knowledge is obtained of the complex processes of the cell division and mutation
and their relation with the host cells, cancer treatments and drugs more specific to the
type of cancer are being developed. There are a number of mechanisms that are triggered
within the normal cells and other body dynamics that have decreased temporarily and
even eradicated the damaged cells. This process is called Spontaneous remission and
regression. This paper explains some of those mechanisms.
II. What is Spontaneous Remission and Regression?
A distinction must be made between Spontaneous Remission (SR) and
Spontaneous Regression (SR). SR refers to the reversal of the disease process that tends
to be more systemic, such as leukemia and lymphomas. SR refers to the reduction and
even full disappearance of solid tumors or neoplasms. The use of the terminologies
applies to realities in which the patient undergoes no Western allopathic medical
treatment or “as a result of a therapy considered inadequate to influence systemic
neoplastic disease.” Both remission and regression has been observed to be temporary
or permanent in the clinical studies. Remission and regression tend to be used
interchangeably. It appears that most studies follow the SR definition by Everson and
Cole which specifies the aforementioned characteristics.
The most often cited occurrences of SR in the every growing medical journalism
point to few of the many types of carcinomas. They include: renal cell cancer, malignant
melanoma, low-grade non-Hodgkin’s lymphoma (NHL), chronic lymphocytic leukemia
(CLL) and neuroblastoma in children.
III. Causes of Spontaneous Remission: Mechanisms
The National Cancer Institute (in the 1970’s) proposed that it was likely
immunological factors that provided the primary mechanism for remission. Since then
others factors have been identified including immune mediation, hormonal factors,
inhibition of tumor growth by growth factors and/or cytokines, differentiation of the
tumor into a more “normal” type of tissue, elimination of carcinogens, angiogenesis,
tumor necrosis, programmed cell death (apoptosis) and genetic factors. Only few of
these mechanisms are studied here.
1. Apoptotic Mechanism
One exciting mechanism that results in SR is that of apoptosis. Our body is a
conglomeration of multiple cells of particular types that form the different parts of our
body: organs, tissue, bone, etc. Normal cells continually develop and die within the
group or type to which they belong. Abnormal cells can develop within the normal cells
leading to malignancies. Apoptosis is presented as a programmed cell death orchestrated
by a series of biochemical events. Cell death by apoptosis is a process by which bodies
of cell(s) give up their life and are disposed of in a way that would not harm the
organism. In the event of cancerous cells, the body may follow an intrinsic biological
path that would make those malignant cells to die. In the event of cancerous mass, no
matter what the size of it is, the tumor could decrease even to the point of total
disappearance in the apoptotic process.
Authors point at cases where the mechanism of apoptotic cell death, intrinsic to
the organism, apparently could be more beneficial in some carcinogens than the repeated
processes
...
...